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What Limits Interpretation of Klow Preclinical Data

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In earlier intranasal studies, higher doses of PT-141 caused increases in blood pressure and were the reason trials were paused

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The incretin glucagon-like peptide-1 (GLP-1), released from the gut during food intake, amplifies glucose-stimulated insulin release by binding to and activating its cognate G protein-coupled receptor (GPCR), the GLP-1 receptor (GLP-1R), triggering cAMP generation and downstream Protein Kinase A (PKA) and Exchange Protein Activated by cyclic AMP 2 (Epac2) signalling 4 , a process that has been exploited to develop pharmacological GLP-1R agonists (GLP-1RAs) as T2D therapies