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End Stage Renal Disease (ESRD) patients on maintenance hemodialysis may have low plasma carnitine concentrations and an increased ratio of acylcarnitine/carnitine because of reduced intake of meat and dairy products, reduced renal synthesis and dialytic losses

The Phase 3 programme , understood to be known as the TRIUMPH trials, is now underway and is evaluating retatrutide across broader and more diverse patient populations, including individuals with: Obesity without type 2 diabetes Obesity with type 2 diabetes Obesity-related cardiovascular disease Metabolic dysfunction-associated steatohepatitis (MASH) Readers seeking the most current information on trial status, registered populations, and endpoints are encouraged to consult ClinicalTrials.gov directly, where Phase 3 trial registrations for retatrutide can be found

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Diabetes Care 2013;36:1789-1796

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