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If you take levothyroxine (or liothyronine, natural desiccated thyroid, or any thyroid hormone replacement), GLP-1 medications can affect how your body processes that medication in several important ways

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[1] [2] Additionally, oral semaglutide (Rybelsus) can increase levothyroxine exposure

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CrossRef Elevated adipose inflammation, but reduced hepatic triacylglycerol storage in diet-induced obese Plin4/ mice Atanaska Ivanova Doncheva, Ryoko Higa, Prabhat Khanal, Martine Villemo ksenvg Ingebrigtsen, Yuchuan Li, Shrikant Kolan, Pratibha Kolan, Ales Kvasnicka, Ingunn Jermstad, Shaista Khan, Bjrn Steen Sklhegg, Svein Olav Kolset, Hilde Nebb, Marit Hjorth, Fro Journal of Biological Chemistry .2026