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In the SURMOUT-1 trial 2,539 patients underwent randomization to tirzepatide or placebo and were followed for 72 weeks demonstrating up to 20.9% weight reduction with maintenance dosing versus 3.1% in the placebo group for a net 17.8% weight reduction [35]

The impact of weight cycling on obese patients has not been determined so far, so more individual level data may be more meaningful to clinical practice

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