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In trials, retatrutide produced larger average weight loss (about 24.2% at 48 weeks versus roughly 20.9% for tirzepatide at 72 weeks)

We address these gaps in knowledge by investigating the effect of Glp1r agonist treatment in obese male mice on food intake, meal patterns, and body weight-adjusted EE throughout a chronic dosing regimen and following cessation of treatment

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Third, immortal time bias may artificially inflate apparent protective effects if the period between cohort entry and treatment initiation is misclassified as exposed time