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(PMID: 16186419) Wang, Zhang, Huang, and colleagues published a dose-response meta-analysis in PLoS ONE in 2017, analyzing nine prospective studies with 527,589 participants

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However, benefits were still observed across the BMI spectrum, and the effects were generally consistent across multiple subgroups, including those with mildly reduced versus preserved ejection fraction, and those receiving versus not receiving other heart failure medications like mineralocorticoid receptor antagonists and SGLT2 inhibitors at baseline