Glutamate synthesis and degradation in differently located astrocytes was envisaged to present a possible problem in the suggested interacting pathways of glutamate production and oxidation with its exclusive use of aspartate aminotransferase (Figure 3B) rather than GDH (Hertz, 2011a)
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Altogether, these interrelated mechanisms create a pathological environment and further progressive neuronal damage, forming the biological basis of neurodegenerative diseases