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18 non-RCTs [11, 63,64,65, 69, 70, 73, 74, 76, 86, 91, 93, 96, 103, 109, 153, 161, 164] were included, with 27 independent and 2 cross-over intervention groups (24 CR and 5 EX groups), involving 757 participants

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Our data suggest that GCLM KO mice have higher capacities for ethanol and acetaldehyde clearance, which may contribute to the protective phenotype

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