The six-amino-acid structure (N-hexanoic-Tyr-Ile-(6) aminohexanoic amide) is susceptible to cleavage by pepsin and trypsin, meaning any dihexa that survives gastric pH is cleaved in the duodenum
Some are used clinically under supervision for diagnostic or therapeutic applications, and others are frequently used off-label
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However, although erastin shows antitumor effects, it has not entered clinical trials because it is poorly soluble in water, and its metabolism in vivo is unpredictable
Cells The cell lines BEAS-2B, H1975, H1650, A549, H1299, and the engineered primary human lung adenocarcinoma cells pLUAD1 were obtained from the Thoracic Surgery Laboratory at the First Affiliated Hospital of Soochow University