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Disruption of -TrCPPER interactions in cells lengthens period or dampens rhythms, while inducible knockout of -TrCP2 in mice leads to disrupted behavioral rhythms and variable period lengths under DD (Reischl et al., 2007

10.1152/physrev.00007.2017 105 PelkeyK

(2) This antioxidant action may have been partly attributable to the presence of copper, which is posited to support SOD enzymatic function

58 While 15d-PGJ2 can protect mice against lethal pulmonary inflammation, the molecule is unstable and poorly soluble making it less favorable for therapy