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Gaceta Cientfica Efectividad comparativa de los agonistas del receptor GLP-1 sobre el control glucmico, el peso corporal y el perfil lipdico en la diabetes tipo 2 OBJETIVO Evaluar la eficacia comparativa y la seguridad de los agonistas del receptor del pptido 1 similar al glucagn (GLP-1RA) sobre el control glucmico, el peso corporal y el perfil lipdico en adultos con diabetes tipo 2

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Results Descriptive analysis During the study period, a total of 6,437,182 AE reports were obtained from the FAERS database after exclusion of duplicates, containing 11,326 semaglutide-related gastrointestinal AEs in 5,442 patients

In rodent models, both GLP-1 and exendin-4 appear to influence reproductive efficiency via interaction with the hypothalamic kisspeptin (Kiss-1) system (Outeirino-Iglesias et al., 2015)