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Despite the benefits of GLP-1 RAs for managing weight and blood glucose levels in women of childbearing age, these medications are not advised during pregnancy because of concerns regarding fetal effects observed in animal studies

Wegovy is specifically formulated for weight loss with a maximum dose of 2.4 mg weekly

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The supernatants were transferred into a new tube containing a SpinX HPLC 0.2-m nylon microcentrifuge filter (Costar, Corning, NY, United States), centrifuged again at 10,000 g for 2 min at 4C, and stored at 80C until used

The reproductive endpoints that matter most in PCOS ovulation rate, menstrual regularity, free-androgen index, SHBG, fertility have simply never been measured in a retatrutide trial