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After that, cells were washed with ice-cold PBS and lysed by 50 L lysis buffer (PBS supplemented with 20 mM Tris-HCl and 1% (v/v) Triton X-100, pH 7.4)

doi: 10.1016/S2468-1253(22)00317-X National Institute of Diabetes and Digestive and Kidney Diseases

Class IC Class IC antiarrhythmic drugs produce the strongest sodium channel blockade among Class I agents, with high-affinity, use-dependent binding that slows conduction through atrial tissue, ventricular myocardium, and the His-Purkinje system (21)(22)(32)

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Any future role will depend on earlier or different targets and still needs to be proven