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Finally, although the correlations between the metabolome and microbiome were established using robust statistical analyses, there was limited statistical power and there are also limitations to the statistical approaches used herein (e.g., log transformation to resolve non-normal distribution and/or heteroscedasticity 103 )

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The selected per-injection dose remains fixed at 1.64.8 mg across all three phases, while frequency changes from daily to 5 per week to 23 per week for maintenance, followed by 48 weeks off

1 Introduction Nasal drug delivery has increasingly garnered significant attention in recent years as a non-invasive drug delivery route