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A possible explanation for unexpected or contrasting observations is that forcing the plant to overproduce PCs caused a severe GSH depletion, which disables GSH in fulfilling its other important functions in antioxidative defense and signaling

Decrease in this fluorescent signal by H 2 was not only observed in cultured cells, but also in various tissues as shown in testicular radioprotection [19], hematopoietic stem cell damage by total body irradiation [20], and hyperoxia in cultured cells [21], lung hypoxia/reoxygenation [22], retinal ischemia-reperfusion [23], and retinal sonication [24]

Kamhieh-Milz J, Bal G, Sterzer V, Kamhieh-Milz S, Arbach O, Salama A