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More serious but less common adverse effects require medical attention

A subset of people with severe obesity carry rare, highly penetrant genetic variants that can result in severe childhood-onset obesity

No dramatic overnight transformation, just steady progress

these principles are consistent with Enhanced Recovery After Surgery (ERAS) recommendations ( 8.5 Evidence gaps and future directions Although microbiota-based interventions have demonstrated benefits for liver-related outcomesmost notably rifaximin for HE and probiotics/synbiotics for postoperative infectious complicationsdirect evidence for POD prevention remains extremely limited

While they can be highly effective, not everyone is an ideal candidate