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B12 deficiency can develop gradually during long-term GLP-1 agonist use and contributes to fatigue, cognitive fog, and neuropathy

That is a valid reason

2012 found exenatide and liraglutide enhanced stress-induced corticosterone in mice at doses above human clinical equivalents

Their presence (or sudden absence) provides indirect evidence about whether the medication is working at full strength

First month results in clinical trials showed an average weight loss of approximately 3.8 percent of baseline body weight at the 2.4 mg dose, but most researchers are still at 0.25 mg during this period