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The science is new, and the impact of GLP-1s on bipolar disorder isnt fully known , so talk to your psychiatric prescriber first and monitor for any mood changes

GSM-directed therapy in peri/postmenopausal patients (or others with hypo-oestrogen states): NICE and UK resources support vaginal oestrogen as a local therapy for genitourinary symptoms of menopause, with patient counselling that systemic absorption is minimal and serious adverse effects are very rare

Yes, caffeinated beverages like coffee and tea count toward your daily fluid intake and are generally safe in moderation (up to 400mg caffeine daily)

This study has multiple strengths

This occurred after the drug received FDA approval and after adverse health reactions were reported to the FDA (postmarketing experiences)