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Variants in GLP1R (the GLP-1 receptor itself), GIPR (the GIP receptor that tirzepatide uniquely engages), FTO (appetite regulation), MC4R (satiety signaling), and TCF7L2 (insulin response) are associated with differential response patterns to semaglutide and tirzepatide

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Monitor for side effects and tolerability during transitions between semaglutide products

& Honigmann, A

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