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Its because of its possible synergistic effects

This rebound effect contributes significantly to weight regain patterns observed after cessation of appetite-modifying medications

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Patients included in the trial had diabetes and fulfilled the following criteria for kidney disease at the time of randomization: a urinary albumin-to-creatinine ratio (UACR) of 30300 (mg/g), estimated glomerular filtration rate (eGFR) of 2560 (ml/min/1.73m 2 ), or a UACR of 3005000 and eGFR of 2575 (ml/min/1.73m 2 ) along with diabetic retinopathy (see 17 for further details)

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