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Ipamorelin is a synthetic pentapeptide belonging to the group of ghrelin mimetics, acting as a selective agonist of the GHS-R1a receptor (Growth Hormone Secretagogue Receptor)

The bond is formed from the COOH in the R group of glutamic acid, not the COOH

As a result, these subjects require twofold to threefold higher daily doses of nortriptyline (an antidepressant and a CYP2D6 substrate) to achieve therapeutic plasma levels

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Currently, the conventional treatment of SLE mainly involves glucocorticoids and immunosuppressants (Ugarte-Gil and Alarcn, 2014