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When processed in KEGG for bioinformatic surveillance, this dataset provided additional evidence of a marked metabolic shift associated with GLP-1 agonist treatment, with a fold enrichment of 28.4 affecting the oxidative phosphorylation pathway, representing the presence of 12 significantly downregulated genes relevant to the progression of substrates through this pathway

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For example, propionate exerts anti-inflammatory and antioxidant effects by reducing cell surface CD14 expression and influencing the translocation of Nuclear Factor Erythroid 2-Related Factor 2 (110)

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Lizneva D, Suturina L, Walker W, Brakta S, Gavrilova-Jordan L, Azziz R