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If side effects appear at a higher dose, return to the previously tolerated dose

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Mechanistically, dietary spermidine crosses the blood-brain barrier in mice, increasing hypusination of eukaryotic translation initiation factor 5A (EIF5A) and mitochondrial function in the hippocampus while reducing mitochondrial decay

Anita Gupta of the Johns Hopkins School of Medicine, who served on FDA's compounding committee until earlier this year

It regulates how quickly our mitochondria produce adenosine triphosphate (ATP), the energy currency of our body, and in doing so, underpins metabolism and the health of every body system