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However, GHK with two net positive charges leads to lower cell membrane adsorption than the two chimeric peptides (Figure 3D)

The global market for nasal drug delivery in patients was valued at approximately $85.89 billion in 2025 and is projected to reach $119.56 billion by 2029 at a compound annual growth rate (CAGR) of 8.6% (The Business Research Company, 2025)

(2001) Roles of growth hormone and insulin-like growth factor 1 in mouse postnatal growth

Biol Psychiatry (2000) 48:81329.10.1016/S0006-3223(00)01020-9 110 LyooIKSungYHDagerSRFriedmanSDLeeJYKimSJet alRegional cerebral cortical thinning in bipolar disorder

Both cell lines were maintained under standard conditions in specific DMEM/F-12 media supplemented with serum