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The major species of bacteria that process tryptophan via the tryptophanase pathway are Lactobacillus genera of the Firmicutes phylum The AroAT (also abbreviated ArAT) pathway of microbial tryptophan catabolism yields indole-3-pyruvic acid (IPyA) which is then converted to indole-3-lactic acid (ILA) which is then converted to indole-3-acrylic acid (IA), which is finally converted to indole-3-propionic acid (IPA

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In more advanced cases, it may cause delirium, loss of balance, low body temperature and low blood pressure

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