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This state is characterized by increased collagen I and -SMA expression, as well as disruption of the MMP/TIMP balance, culminating in pathological ECM accumulation
A recent study showed that glucose metabolism was dysregulated and that pyruvate supplementation could prevent neurodegeneration in an animal model of glaucoma 31 , suggesting that ATP production from glycolysis is disrupted, and that other energy fuel pathways, such as -oxidation, may be augmented to compensate for the reduction in energy metabolism
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