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FDA also described BPC-157 as insufficiently characterised for safety and effectiveness, with limited human information and potential immunogenicity concerns

Remarkably, some studies have found that berberines effect on lowering blood glucose is comparable to that of metformin , a first-line diabetes drug [3], [8]

The study introduces an integrative framework that combines network pharmacology, MR, and transcriptomic validation, providing a data-driven approach to identify DM2 DMTs with the highest potential for AD prevention in DM2 and bridging the gap between computational predictions and clinical relevance