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Interestingly, supraphysiological ROS levels may inhibit PAD activity, as observed in studies showing that H 2 O 2 concentrations above 40 M directly suppress PAD2 and PAD4 activity (78)

Lewis, Elliott, MD

Arginine and polyamines in Helicobacter pylori-induced immune dysregulation and gastric carcinogenesis

Conversely, regulator of G protein signaling 20 facilitates NSCLC proliferation by activating autophagy through suppressing the PKA-Hippo pathway (23)

Here, when the two peptides were administered at a 30-min interval, the plasma concentration of the first peptide returned to baseline upon administration of the second peptide