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Mitochondrial DNA damage and apoptosis by ROS Apoptosis is generally induced by the activation of cell surface death receptors (exogenous pathways) that are initiated mainly by the binding of death ligands of the TNF superfamily of cytokines, including TNF, Fas-ligand, and TNF-related apoptosis-inducing ligand with their death receptors TNF receptor 1, Fas (also known as CD95), and DR4 or DR5, respectively

Research consistently shows that the best outcomes occur when pharmaceutical therapy is combined with structured nutrition counseling , exercise guidance , and behavioral modification support

Metabolism (1977) 26:3516

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