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The DPP-4 inhibitor isoleucin-thiazolidide was found to augment insulin secretion and improve glucose tolerance in association with prolonging the half-life of GLP-1 in lean and obese Zucker rats ( First Clinical Study With DPP-4 Inhibition NVP DPP728 in Animals The first DPP-4 inhibitor which was used in a clinical study in type 2 diabetes was NVP DPP728

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Val 8-glucagon-like peptide-1 protects against Abeta1-40-induced impairment of hippocampal late-phase long-term potentiation and spatial learning in rats

doi: 10.1186/s40798-017-0076-1, 194

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