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Common symptoms of a haemolytic episode include: Sudden onset of fatigue and weakness often the earliest sign Pallor or yellowing of the skin and eyes (jaundice) caused by the release of bilirubin from broken-down red blood cells Dark or tea-coloured urine a hallmark sign indicating haemoglobin is being excreted through the kidneys Shortness of breath and rapid heart rate Abdominal or back pain Dizziness or light-headedness These symptoms can be mistaken for other conditions, including viral illness or a urinary tract infection particularly problematic given that some UTI treatments (such as nitrofurantoin) are themselves triggers

doi: 10.3390/molecules27072157