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Medical Pharmacology Chapter 2: General Principles: Pharmacokinetics Cytochrome P450 Enzyme Induction: Following repeated administration, some drugs increase the amount of P450 enzyme usually by: Increase enzyme synthesis rate (induction) Reduced enzyme degradation rate Cytochrome P450 enzyme inhibition: Certain drugs, by binding to the cytochrome component, act to competitively inhibit metabolism

Efficacy Trade-Offs: What the Clinical Evidence Shows Lower cost does not equate to lower efficacy

There has been shown benefit on lowering blood pressure, improving blood cholesterol, often leading to less medication needed for the treatment of these conditions, she added

Planta 210: 295-301

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