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A deficiency in B12 can lead to a significant decrease in energy and exercise tolerance, along with fatigue

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It is to be understood that the heteroatom linkers may be used to covalently attach any of the radicals described herein, including drug radicals D to the polyvalent linker, ligand radicals B to the polyvalent linker, or various di and polyvalent radicals that from the polyvalent linker L Illustrative additional bivalent radicals that can be used to form part of the linker are as follows

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While the medication starts working as soon as its administered, significant appetite reduction usually takes a few days to weeks