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Pickart and colleagues reported in Nature (1980) that the tripeptide facilitates copper uptake into cultured cells, and potentiometric titration places the GHK-Cu stability constant at log K of approximately 16.4, marginally above the copper transport site of human serum albumin at roughly 16.2

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Chaichompoo P, Svasti S, Smith DR

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Epigenetic modifications, such as DNA methylation, histone modifications, and interactions with non-coding RNAs (e.g., MALAT1, PVT1, MIR4435-2HG, and TUG1), are essential for regulating NRF2 expression by modulating chromatin architecture and gene accessibility