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To mitigate IGF-1 side effects such as joint pain, swelling, and nerve compression, bodybuilders can follow several strategies: use the lowest effective dose under medical supervision, rotate injection sites, maintain proper hydration, support joints with supplements like glucosamine or omega-3 fatty acids, and incorporate stretching and mobility exercises

Cell metabolism , 21 (3), 443454

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Peptides 77:2837 Holst JJ et al (2018) Mechanisms in bariatric surgery: gut hormones, diabetes resolution, and weight loss