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A., Wilkinson, J
Rice ascorbate peroxidase gene family encodes functionally diverse isoforms localized in different subcellular compartments
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As emphasized by Varma and colleagues, traditional single-layer kill-switch mechanisms often exhibit instability and may lose functionality within days, whereas multilayered systemsparticularly those combining CRISPR-inducible modules, toxinantitoxin systems, and synthetic auxotrophiesdemonstrate markedly greater robustness, maintaining containment across hundreds of generations (Varma et al., 2025)
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