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The following individual and combined search terms were used: GLP-1, Semaglutide and Liraglutide, molecular mechanism, lipid metabolism, insulin metabolism, glucose homeostasis, energy expenditure obesity treatment, type 2 diabetes mellitus, side effects, clinical trials, treatment option, fatty liver disease, hypertension, neurodegenerative diseases, cardiovascular diseases, therapeutic options. Only articles published in the last 10 years are included, although older pivotal studies were added

Multiple Endocrine Neoplasia Syndrome Type 2 (MEN 2) This genetic disorder increases the risk of certain cancers, including thyroid cancer , making Semaglutide and Tirzepatide unsuitable choices

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Furthermore, with a run-in phase of a low-calorie diet, total weight loss of up to 12.5 kg can be achieved (of which half [6.2%] was observed during the liraglutide 3.0 mg treatment period) in subjects with obesity (176)

Nausea is particularly typical during the initial stages of treatment, though it generally improves after a period of adjustment