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Gene-Expression Modulation Pickart and Margolina (2018) reviewed gene-expression data indicating that GHK-Cu influences the transcription of a large set of genes involved in tissue remodeling, DNA repair, and antioxidant and inflammatory pathways, framing the apo-peptides copper-coordination chemistry as central to these reported effects [2]

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To that end, there are reputable clinics in the United States that prescribe KPV and other restricted peptides, though they are still few and far between