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The prolongation of apparent half-life with multiple dosing is characteristic of drugs that undergo distribution into deep tissue compartments from which elimination is slow, creating a multi-exponential elimination profile

In clinical practice, a notable 4060% of individuals diagnosed with depression demonstrate nonsuppression in the dexamethasone suppression test, indicative of compromised negative feedback mechanisms within the HPA axis (29)

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The peptide does not correspond to any naturally secreted hormone or growth factor