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In some of these clinical studies, liraglutide treatment had been used for up to 52 weeks at doses ranging up to 3 mg daily (only in nondiabetic obese populations) or up to 1.8 mg daily (patients with type 2 diabetes) with no systematic change in calcitonin concentrations indicating any measurable response to GLP-1 receptor stimulation (34)

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What makes GLP-1 agonists so effective compared to naturally occurring GLP-1 is that the amino acid sequence of GLP-1 has been modified to make the agonists resistant to being broken down by the enzymes that break down GLP-1, the complaint reads