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CrAT is present in mitochondria and peroxisomes 31,32 and transfers the acetyl moiety from acetyl-CoA onto carnitine to generate acetylcarnitine for organelle export via the carnitine-acylcarnitine translocase (CACT

This supplement is commonly chosen for antioxidant support and healthy-aging routines

Notably, multi-omics analysis uncovers a novel whereby AA-CDs directly target and stabilize heat shock protein A5 (HSPA5), thus preventing the degradation of glutathione peroxidase 4 (GPX4), a pivotal negative regulator of ferroptosis

Given the typically elevated cardiovascular risk in AD patients, we hope that future studies will uncover whether variations in Lp(a) levels might differently affect cardiovascular risk in RA and other AD patients