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However, dulatglutide failed to raise force of contraction above pre-drug levels (Ctr)

A GLP1 prescription could indicate: Well-controlled type 2 diabetes Severe obesity under active treatment Metabolic dysfunction associated steatohepatitis (MASH) Obstructive sleep apnea Elevated cardiovascular risk Chronic kidney disease Clinically, those are very different scenarios with very different mortality implications

Layer 2: Peptides optimize the systems that hormones support but dont fully restore

Bandelow B, Zohar J, Hollander E, Kasper S, Mller HJ

Some studies suggest potential benefits, while others raise concerns about efficacy and safety