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Supporting cellular health: Promotes DNA repair and overall cell function

We propose that an age-related oxidative redox shift overwhelms energetic capacity to promote pathogenic impairment of proteostasis and downstream synapse loss and cognitive decline in AD

Given the heterogeneity of outcomes, it is clinically useful to identify modifiable, mechanism-level risk factors early

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suggested that liraglutide improved serum lipid profile and hepatic steatosis by inducing autophagy through the adenosine monophosphate activated protein kinase (AMPK)/mammalian target of rapamycin (mTOR) pathway [11], which has a key role in autophagy modulation [34]