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Then using a H 2 O 2 -induced senescent TM3 Leydig cell model, we found that FOXO4 maintains the viability of senescent Leydig cells and that the FOXO4 blocker FOXO4-DRI induces apoptosis in these senescent cells

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For example, prior studies have identified that urine from IC/BPS patients experiencing pain and low bladder capacity have a significantly increased abundance of active neutrophil elastase 23 , a serine protease with relatively broad substrate specificity 59

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Lucas ES, Dyer NP, Murakami K, Hou Lee Y, Chan YW, Grimaldi G, et al