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TNF-, tumor necrosis factor-alpha

Two 16-week phase 1 trials, one in subjects with obesity and another with T2D, shows significant reductions in body weight and HbA1c, respectively ( 2 without T2D demonstrates mean body weight losses of 6.8%, 13.6%, 16.7%, 18.7%, and 2.0% with 0.6 mg, 2.4 mg, 3.6 mg, 4.8 mg, and placebo, respectively ( 2 treated with survodutide 0.3, 0.9, 1.8, 2.7 mg weekly, 1.2 mg and 1.8 mg twice weekly, compared to semaglutide 1.0 mg weekly or placebo shows mean HbA1c percentage point reductions of 0.9, 1.5, 1.7, 1.6, 1.6, 1.7, 1.5, and 0.2, respectively, as well as mean body weight reductions significantly greater than placebo at all treatment doses, the highest being 8.7% for the 1.8 mg twice a week dose ( 3.5.4 Cotadutide Cotadutide is a GLP-1 and glucagon receptor co-agonist administered subcutaneously once daily

The Lancet (2021) This Phase 2 dose-finding trial randomized adults with overweight or obesity without diabetes to cagrilintide at doses from 0.3 to 4.5 mg weekly, placebo, or liraglutide 3.0 mg daily as an active comparator across 57 sites in 10 countries

HUBERMAN: I also have a JOOV whole body panel, and I use that about three or four times a week

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