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52 Additionally, ERdj5 catalyzes disulfide bond reduction and unfolds proteins, ensuring efficient substrate translocation into the cytoplasm for ERAD

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Sulfation is required for degradation of heparin (released alongside histamine from mast cell granules)

These include the development of next-generation glucagon-like peptide-1 receptor agonists (GLP1Ras), with their weight loss efficacy ranging from 12% to 15% for semaglutide and 20% for tirzepatide ( One salient concern regarding the use of GLP1Ras for older adults is their impact on skeletal health ( Given the rapid and increasing uptake of GLP1Ra-based therapies, coupled with the knowledge gap surrounding their impact on clinically relevant bone outcomes in older adults, we conducted an exploratory post hoc analysis of a pilot trial to explore the impact of 20 weeks of semaglutide use on bone density and turnover in older adults with overweight or obesity