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Gene sets used were obtained from built-in Gene Ontology or curated databases v7.5 (Broad Institute) or described previously 78

Therefore, we emphasize a risk-factor-based escalation model, where comorbidities, treatment response, and functional limitations guide progression through treatment steps

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Our results with the CAGF cloning method also suggest an important function of Tyr 6 in glutathione binding, therefore, the screening results are consistent with the crystallographic data