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Androgen deficiency: Cases of androgen deficiency have occurred with use of opioids for an extended period of time (see CLINICAL PHARMACOLOGY)

Additionally, the public participation information has changed as follows: On July 23, 2026, the start times for oral presentations from the public have changed from approximately 10:15 a.m., 11:50 a.m., 2:15 p.m., and 4:00 p.m

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Pulmonary fibrosis studies using bleomycin-induced injury show reduced inflammatory cell infiltration and interstitial thickness at doses of 2.6-260 g/mL/day