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It is a 39-amino acid synthetic peptide that targets both the glucose-dependent insulinotropic polypeptide (GIP) receptor and the glucagon-like peptide-1 (GLP-1) receptor simultaneously

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When similar types of stimulation are applied prior to paired associative stimulation (PAS) with a 25-ms interval, which is a protocol to induce long-term potentiation-like plasticity in M1, PAS can be bidirectionally modulated: cTBS cerebellum and cathodal tDCS cerebellum lead to significant enhancement of PAS-induced M1 plastic effect above the ShamTBS cerebellum +PAS M1 level, while iTBS cerebellum and anodal tDCS cerebellum lead to its abolition [247, 248]

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