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Microneedling the scalp before application is a common practice to improve delivery, and some limited evidence supports this approach

J Zhejiang Univ Sci B 16:948956 Jin ZG, Ueba H, Tanimoto T, Lungu AO, Frame MD, Berk BC (2003) Ligand-independent activation of vascular endothelial growth factor receptor 2 by fluid shear stress regulates activation of endothelial nitric oxide synthase

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However, absorption challenges and individual variability in effectiveness have led many Richmond healthcare providers to recommend vitamin B12 injections as a more reliable delivery method